Domain Insertion Effectively Regulates the Mechanical Unfolding Hierarchy of Elastomeric Proteins: Toward Engineering Multifunctional Elastomeric Proteins
نویسندگان
چکیده
منابع مشابه
Domain insertion effectively regulates the mechanical unfolding hierarchy of elastomeric proteins: toward engineering multifunctional elastomeric proteins.
The architecture of elastomeric proteins controls fine-tuned nanomechanical properties of this class of proteins. Most elastomeric proteins are tandem modular in structure, consisting of many individually folded domains of varying stability. Upon stretching, these elements unfold sequentially following a strict hierarchical pattern determined by their mechanical stability, where the weakest ele...
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Elastomeric proteins have evolved independently multiple times through evolution. Produced as monomers, they self-assemble into polymeric structures that impart properties of stretch and recoil. They are composed of an alternating domain architecture of elastomeric domains interspersed with cross-linking elements. While the former provide the elasticity as well as help drive the assembly proces...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.3367